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Component | Class | Efficacy | Length of Immunity | Risk/Severity of Adverse Effects | Comments |
| Canine Distemper | Core | High | > 1 year for modified live virus (MLV) vaccines | Low | |
| Measles | Noncore | High in preventing disease, but not in preventing infection | Long | Infrequent | Use in high risk environments for canine distemper in puppies 4-10 weeks of age |
| Parvovirus | Core | High | > 1 year | Low | |
| Hepatitis | Core | High | > 1 year | Low | Only use canine adenovirus-2 (CAV-2) vaccines |
| Rabies | Core | High | Dependent upon type of vaccine | Low to moderate | |
| Respiratory disease from canine adenovirus-2 (CAV-2) | Noncore | Not adequately studied | Short | Minimal | If vaccination warranted, boost annually or more frequently |
| Parainfluenza | Noncore | Intranasal MLV - Moderate Injectable MLV - Low | Moderate | Low | Only recommended for dogs in kennels, shelters, shows, or large colonies; If vaccination warranted, boost annually or more frequently |
| Bordetella | Noncore | Intranasal MLV - Moderate Injectable MLV - Low | Short | Low | For the most benefit, use intranasal vaccine 2 weeks prior to exposure |
| Leptospirosis | Noncore | Variable | Short | High | Up to 30% of dogs may not respond to vaccine |
| Coronavirus | Noncore | Low | Short | Low | Risk of exposure high in kennels, shelters, shows, breeding facilities |
| Lyme | Noncore | Appears to be limited to previously unexposed dogs; variable | Revaccinate annually | Moderate | |
A possible vaccination schedule for the 'average' dog is shown below.
Dog Vaccination Schedule |
AgeVaccination |
| 5 weeksParvovirus: for puppies at high risk of exposure to parvo, some veterinarians recommend vaccinating at 5 weeks. Check with your veterinarian. |
6 & 9 weeksCombination vaccine* without leptospirosis.
Coronavirus: where coronavirus is a concern. |
| 12 weeks or olderRabies: Given by your local veterinarian (age at vaccination may vary according to local law). |
12 & 15 weeks**Combination vaccine
Leptospirosis: include leptospirosis in the combination vaccine where leptospirosis is a concern, or if traveling to an area where it occurs.
Coronavirus: where coronavirus is a concern.
Lyme: where Lyme disease is a concern or if traveling to an area where it occurs. |
Adult (boosters)§Combination vaccine
Leptospirosis: include leptospirosis in the combination vaccine where leptospirosis is a concern, or if traveling to an area where it occurs.
Coronavirus: where coronavirus is a concern.
Lyme: where Lyme disease is a concern or if traveling to an area where it occurs.
Rabies: Given by your local veterinarian (time interval between vaccinations may vary according to local law). |
| *A combination vaccine, often called a 5-way vaccine, usually includes adenovirus cough and hepatitis, distemper, parainfluenza, and parvovirus. Some combination vaccines may also include leptospirosis (7-way vaccines) and/or coronavirus. The inclusion of either canine adenovirus-1 or adenovirus-2 in a vaccine will protect against both adenovirus cough and hepatitis; adenovirus-2 is highly preferred.
**Some puppies may need additional vaccinations against parvovirus after 15 weeks of age. Consult with your local veterinarian.
§ According to the American Veterinary Medical Association, dogs at low risk of disease exposure may not need to be boostered yearly for most diseases. Consult with your local veterinarian to determine the appropriate vaccination schedule for your dog. Remember, recommendations vary depending on the age, breed, and health status of the dog, the potential of the dog to be exposed to the disease, the type of vaccine, whether the dog is used for breeding, and the geographical area where the dog lives or may visit.
Bordetella and parainfluenza: For complete canine cough protection, we recommend Intra-Trac II ADT. For dogs that are shown, in field trials, or are boarded, we recommend vaccination every six months with Intra-Trac II ADT. |
Researchers at the Veterinary Schools at the University of Minnesota, Colorado State University, and University of Wisconsin suggest alternating vaccinations in dogs from year to year. Instead of using multivalent vaccines (combination vaccines against more than one disease), they recommend using monovalent vaccines which only have one component, e.g., a vaccine that only contains parvovirus. So, one year your dog would be vaccinated against distemper, the next year against canine adenovirus-2, and the third year against parvovirus. Then the cycle would repeat itself. Other researchers believe we may not have enough information to recommend only vaccinating every 3 years. Manufacturers of dog vaccines have not changed their labeling which recommends annual vaccinations. Again, each dog owner must make an informed choice of when to vaccinate, and with what. Consult with your veterinarian to help you make the decision.
Downloadable Vaccination Record Keeper, brought to you by United Kennel Club, Inc.

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References and Further Reading
Al-Sarraf, R. Update on feline vaccine-associated fibrosarcomas. Veterinary Medicine. 1998;729-35.
American Association of Feline Practitioners/Academy of Feline Medicine. Recommendations for Feline Leukemia Virus Testing. The Compendium on Continuing Education for the Practicing Veterinarian. 1997;1105-7.
Bell, FW. Recommendations for FeLV- and FIV-positive cats with cancer. In August, JR (ed.) Consultations in Feline Internal Medicine. W.B. Saunders Co. Philadelphia, PA; 1997;572-8.
Bergman, PJ; Couto, CG; Hendrick, MJ; Macy, DW; Richards, JR; Starr, RM (contributors). Vaccine-associated feline sarcoma symposium. Sponsored by the Vaccine-Associated Feline Sarcoma Task Force and the Arm & Hammer Division of Church & Swight Co., Inc. July 25, 1998.
Brakeman, L (ed.) Researchers suspect genetic cause for vaccine site sarcomas. dvm 1998; July 1, 41-45.
Cole, R. Rethinking canine vaccinations. Veterinary Forum; 1998 Jan;52-7.
Greene, CE. Immunoprophylaxis and immunotherapy. In Greene, CE (ed.) Infectious Diseases of the Dog and Cat. W.B. Saunders Co. Philadelphia, PA; 1998;717-750.
Jarrett, O. Development of vaccines against feline leukemia virus. In Kirk, RW; Bonagura, JD (eds.) Current Veterinary Therapy XI. W.B. Saunders Co. Philadelphia, PA; 1992;457-60.
Klingborg, DJ; Hustead, DR; Curry-Galvin, EA; Gumley, NR; Henry, SC; Bain, FT; et al. AVMA Council on Biologic and Therapeutic Agents' report on cat and dog vaccines. Journal of the American Veterinary Medical Association. November 15, 2002 (Volume 221, No. 10); 1401-1407.
Pfizer Animal Health. Duration of immunity in companion animals after natural infection and vaccination. Pfizer Animal Health; June 30, 1998.
Roitt, I; Brostoff, J; Male, D. Immunology. CV Mosby Company. St. Louis, MO; 1985.
Rosen, DK. Feline infectious diseases and rational vaccine protocols for immunization. Presented at the Wisconsin Veterinary Medical Association Convention. October 10, 1998.
Schultz, RD. Current and future canine and feline vaccination programs. Veterinary Medicine. 1998;233-253.
Tizard, I; Yawei, N. Use of serologic testing to assess immune status of companion animals. Journal of the American Veterinary Medical Association. 1998;213;54-60.
Veterinary Learning Systems. Recombinant vaccine technology. Supplement to The Compendium on Continuing Education for the Practicing Veterinarian. 1997;19(2).
Veterinary Learning Systems. Vaccine technology in the 21st century. Supplement to The Compendium on Continuing Education for the Practicing Veterinarian. 1998;20(8c). |